MSN Slideshow Ranking the 2025 Top 10 Highest Scoring Fantasy Games By a Running Back By Pro Football Network FacebookTwitterReddItFlipLinkedinEmail January 9, 2025 | 8:00 PM EST Share FacebookTwitterReddItFlipLinkedinEmail 1 of 10 In one of the greatest individual performances in NFL history, Saquon Barkley eviscerated the Rams for 302 total yards and two touchdowns. He single handedly carried his fantasy managers to victory this week. The Saints' hot start to the season faded quickly, but back in Week 2, Alvin Kamara ripped the Cowboys for 180 total yards and 4 total touchdowns. Somehow doing it without so much as a single target, Jonathan Taylor carried the ball 29 times for 218 yards and 3 touchdowns against the Titans. Filling in for an injured Kenneth Walker III, Zach Charbonnet had the game of his career against the Cardinals. He carried the ball 22 times for 134 yards and 2 touchdowns, while adding 7 receptions for 59 yards. The Bills struggled against the run all season. In no week was that more paramount than when Derrick Henry torched them for 199 yards and a touchdown, adding 10 more yards and a score through the air. Fantasy managers in need of a Monday night miracle got one from Joe Mixon. The Cowboys had no answer for the Texans back, as he totaled 153 yards and 3 touchdowns in an easy victory. Easily the most surprising name on this list, Sean Tucker amassed 136 yards on the ground, 56 yards though the air, and scored two total touchdowns in a demolition of the Saints. He scored more fantasy points in this game alone than the rest of the season combined. The Commanders had no answer for the NFL's leading rusher, surrendering 198 total yards to Saquon Barkley, as well as two touchdowns. The only player to appear on this list more than once, incredibly, Saquon Barkley owns three of the 10 best games on the season. Barkley totaled 156 yards and two touchdowns against the Saints, tacking o a two-point conversion for good measure. 2024 was a rough year for Kenneth Walker III, as he battled injury and inefficiency. But this week, Walker couldn't be stopped, totaling 116 yards and scoring three touchdowns in a Seahawks loss to the Lions. More Slideshows Every NFL Game Moved Due to Weather Since 2010 Ranking the 2025 Top 10 Highest Scoring Fantasy Games By a Quarterback Top 10 Single Season Passing TD Leaders Ranking the 10 Best Rookie Seasons in NFL History Ranking the Top 10 New England Patriots Players Of All Time 2025 Dynasty Rookie Mock Draft First Round