Take a look at the NFL Week 3 betting odds, and you’ll notice plenty of big favorites and a nearly 20-point difference between the highest projected total and the lowest. Before you lock in your bets for the week, consider these betting trends for every game as we go through the NFL Week 3 spreads and lines!
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NFL Week 3 Odds and Betting Trends
All odds are from DraftKings Sportsbook and trends from Inside Edge.
New York Giants vs. San Francisco 49ers
- Spread
49ers -10.5 - Moneyline
Giants +400, 49ers -535 - Total
45
The New York Giants were the best ATS team last season (13-4) overall and on the road (6-1), but they are one of seven teams to be 0-2 ATS to open 2023.
The San Francisco 49ers were the best team ATS at home last season (7-2) — this is their first of three straight at home.
Tennessee Titans vs. Cleveland Browns
- Spread
Browns -3 - Moneyline
Titans +124, Browns -148 - Total
39.5
The Tennessee Titans were the fourth-best road team ATS last season (6-2) and covered in New Orleans to open the season.
Under tickets have cashed in four straight Cleveland Browns home games.
Atlanta Falcons vs. Detroit Lions
- Spread
Lions -3 - Moneyline
Falcons +136, Lions -162 - Total
46
Due to the late line movement last week, the Atlanta Falcons failed to cover following an outright win. That’s nothing new; they are 3-10 ATS following a W and are again in that spot this week.
Since the beginning of 2021, overs are 5-1 when the Detroit Lions are favored.
New Orleans Saints vs. Green Bay Packers
- Spread
Packers -1.5 - Moneyline
Saints +102, Packers -122 - Total
42.5
Last week went under by 2.5 points at Carolina, moving unders to 11-4 since 2021 following a New Orleans Saints outright victory.
The Green Bay Packers are a sub-.500 team ATS when favored since 2021, failing to cover by an average of 2.3 points (opened as a 2-point favorite).
Denver Broncos vs. Miami Dolphins
- Spread
Dolphins -7 - Moneyline
Broncos +240, Dolphins -298 - Total
48
The Denver Broncos are 4-0 ATS when getting more than a FG since 2022.
MORE: Tua Tagovailoa NFL MVP Odds
Unders were 7-1 at Miami last season — this is the Dolphins’ home opener.
Los Angeles Chargers vs. Minnesota Vikings
- Spread
Vikings -1 - Moneyline
Chargers -110, Vikings -110 - Total
54
The Los Angeles Chargers originally opened as 1-point road favorites. Overs are 6-3-1 since 2021 when the Chargers are in that spot.
Keep an eye on this spread — the Minnesota Vikings are 17-4 outright when favored since the beginning of 2021.
New England Patriots vs. New York Jets
- Spread
Patriots -3 - Moneyline
Patriots -148, Jets +124 - Total
36.5
Under tickets have cashed in six of the last eight games in which the New England Patriots have been favored.
The New York Jets haven’t scored more than 17 points vs. New England since Nov. 9, 2020 (five straight games).
Buffalo Bills vs. Washington Commanders
- Spread
Bills -6.5 - Moneyline
Bills -285, Commanders +230 - Total
44.5
Unders are 11-3 since 2021 when the Buffalo Bills are a road favorite.
Unders are 9-2 since 2021 when the Washington Commanders are a home underdog.
Houston Texans vs. Jacksonville Jaguars
- Spread
Jaguars -8 - Moneyline
Texans +300, Jaguars -380 - Total
43.5
The road team has won and covered three straight meetings in this series.
Unders were 5-0 when the Jacksonville Jaguars were favored last season, but their 2023 season opener went over the projected total by 6.5 points (3.5-point favorite at IND).
Indianapolis Colts vs. Baltimore Ravens
- Spread
Ravens -7.5 - Moneyline
Colts +275, ravens -345 - Total
44
Unders were 7-0 last season when the Baltimore Ravens played a bottom-10 pass offense.
The Indianapolis Colts were 1-6 ATS vs. top-10 run defenses last season.
Carolina Panthers vs. Seattle Seahawks
- Spread
Seahawks -6 - Moneyline
Panthers +195, Seahawks -238 - Total
42
Only three teams are worse ATS on the road since 2021 than the Carolina Panthers (7-11). Two of those teams (DEN and CHI) are also on the road this week.
MORE: Early NFL Week 3 Predictions and Picks Against the Spread
At 5-10 ATS following a win since 2021, the Seahawks are the fourth-worst team in such spots.
Chicago Bears vs. Kansas City Chiefs
- Spread
Chiefs -12.5 - Moneyline
Bears +490, Chiefs -700 - Total
47.5
The Chicago Bears are just 8-15-1 ATS following an outright loss since 2021.
Since the beginning of last season, the Kansas City Chiefs have been the third-worst ATS team at home (3-7-1). The two teams worse than them (BAL and TB) also host games in Week 3.
Dallas Cowboys vs. Arizona Cardinals
- Spread
Cowboys -12 - Moneyline
Cowboys -900, Cardinals +440 - Total
43.5
Since 2021, the Dallas Cowboys are 9-3 ATS as a road favorite, covering by an average of 5.9 points.
Overs are 9-4 in the Arizona Cardinals’ past 13 games vs. top-10 offenses.
Pittsburgh Steelers vs. Las Vegas Raiders
- Spread
Raiders -1.5 - Moneyline
Steelers +102, Raiders -122 - Total
43.5
Unders are 8-4 since 2021 when the Pittsburgh Steelers are favored (opened as a 1-point favorite).
The Las Vegas Raiders have lost six of their past nine games following a loss.
Philadelphia Eagles vs. Tampa Bay Buccaneers
- Spread
Eagles -5 - Moneyline
Eagles -218, Buccaneers +180 - Total
45.5
No team was worse ATS on the road than the Philadelphia Eagles last season (2-6), but they did manage to hold onto the Week 1 cover in New England. Barely.
Five times since the beginning of last season have the Tampa Bay Buccaneers played a top-10 pass defense, and the under tickets have cashed five times.
49ers +7.5 was an UGLY beat, but one bettor at @DKSportsbook won $60,000 on the Rams' backdoor cover.
More at @PFN365 https://t.co/ROqSJTqMWR
— PFN Betting (@PFNBetting) September 18, 2023
Los Angeles Rams vs. Cincinnati Bengals
- Spread
Bengals -2 - Moneyline
Rams +105, Bengals -125 - Total
43.5
Unders are 7-2 since the beginning of last season when the Los Angeles Rams play on the road.
The Cincinnati Bengals are 8-4 ATS following an outright loss since 2021.