Since the NFL Week 2 betting lines re-opened on Sunday night, there has been quite a lot of injury news that has led to some odds shifts across the slate. The most notable injury was Aaron Rodgers tearing his Achilles on Monday night in his New York Jets debut. Since then, the spread for Jets vs. Cowboys has gone up six points, as Dallas is now a nine-point favorite.
But how have the rest of the betting lines changed since Sunday night, and how do we approach Week 2? Do we fade the overreactions from Week 1, or are some of the surprise performances we saw for real? Let’s take a look and give you some early NFL Week 2 predictions and picks as well.
All the NFL betting odds at a moment’s notice — visit our Betting Lines page, bookmark now, and always get the best line and bang for your buck. Our FREE Parlay Calculator and Betting Odds Calculator are also available for your betting process!
NFL Week 2 Betting Lines
All odds are from DraftKings Sportsbook, and the betting lines are as of 10:30 a.m. EST on Sept. 13.
Minnesota Vikings vs. Philadelphia Eagles Odds
- Spread
Opening: Eagles -7.5
Current: Eagles -6 - Moneyline
Opening: Vikings +310, Eagles -390
Current: Vikings +260, Eagles -325 - Total
Opening: 48.5
Current: 49
Injuries to Eagles’ starters such as S Reed Blankenship, RB Kenneth Gainwell, and CB James Bradberry have caused this line to go down 1.5 points. Now I like the Eagles despite their injuries at home against a much worse defense than they saw last week.
NFL Pick and Prediction: Eagles -6 (-115)
Green Bay Packers vs. Atlanta Falcons Odds
- Spread
Opening: Packers -1
Current: Packers -2 - Moneyline
Opening: Packers -108, Falcons -108
Current: Packers -125, Falcons +105 - Total
Opening: 41.5
Current: 40.5
Are the Packers getting a bit overvalued here after their blowout win over the Bears last week? Maybe, but even despite their win over the Panthers, Desmond Ridder’s play hasn’t instilled much confidence in the oddsmakers.
MORE: NFL Survivor Picks Week 2
This is a great matchup for the Falcons, who have one of the best rushing attacks in the NFL. Last season, Green Bay’s defense was 31st in success rate in stopping the run.
NFL Pick and Prediction: Falcons +2 (-112)
Chicago Bears vs. Tampa Bay Buccaneers Odds
- Spread
Opening: Buccaneers -2.5
Current: Buccaneers -3 - Moneyline
Opening: Bears +116, Buccaneers -136
Current: Bears +120, Buccaneers -142 - Total
Opening: 43.5
Current: 41
Another line that might be an overreaction to Week 1. The Buccaneers were expected to be one of the worst teams this season, but suddenly a win against a fraudulent Vikings team has changed public perception this much?
I’ll be keeping an eye on this spread and seeing if I can get the hook with the Bears getting points.
NFL Pick and Prediction: Bears +3.5 if it gets there
Seattle Seahawks vs. Detroit Lions Odds
- Spread
Opening: Lions -4.5
Current: Lions -5.5 - Moneyline
Opening: Seahawks +184, Lions -220
Current: Seahawks +195, Lions -238 - Total
Opening: 50.5
Current: 47.5
This is perhaps the biggest overreaction to Week 1. The Lions don’t beat the Chiefs if not for Kadarius Toney, and the lookahead line for this game was Detroit (-3) before Week 1.
The Seahawks looked terrible against the Rams last week, but you’re getting at least 2.5 points of value here. I grabbed the Seahawks at +6 already.
NFL Pick and Prediction: Seahawks +6 (-110) placed earlier this week
Los Angeles Chargers vs. Tennessee Titans Odds
- Spread
Opening: Chargers -2.5
Current: Chargers -3 - Moneyline
Opening: Chargers -146, Titans +124
Current: Chargers -155, Titans +130 - Total
Opening: 46.5
Current: 45.5
Like the Steelers were last week, the Titans are going to be the most popular underdog of the week with the betting public.
Everyone knows the Titans under Mike Vrabel are very profitable against the spread as underdogs (24-15-1 ATS), and they’re at home against a Chargers team that almost always plays in close games. This almost seems too obvious to the point that I’m worried about falling into a trap with Tennessee.
NFL Pick and Prediction: Lean Titans +3 (-105)
Baltimore Ravens vs. Cincinnati Bengals Odds
- Spread
Opening: Bengals -3
Current: Bengals -3.5 - Moneyline
Opening: Ravens +130, Bengals -154
Current: Ravens +142, Bengals -170 - Total
Opening: 46
Current: 46.5
Last week might have been an aberration for the Bengals as Joe Burrow looked extremely rusty, and they were playing in terrible weather conditions.
The Ravens, meanwhile, won by double digits over the Texans but suffered injuries to key players such as J.K. Dobbins, Marcus Williams, Ronnie Stanley, and Tyler Linderbaum.
I would’ve taken the Bengals (-3), but I missed out before the line moved up. Last season, all three Ravens-Bengals games went under this total, and I’m leaning that way again this week. Baltimore’s defense has had success against Cincinnati recently, and it looks like both offenses are having some early-season growing pains.
NFL Pick and Prediction: Under 46.5 (-110)
Indianapolis Colts vs. Houston Texans Odds
- Spread
Opening: Colts -1.5
Current: Colts -1 - Moneyline
Opening: Colts -112, Texans -104
Current: Colts -115, Texans -105 - Total
Opening: 40.5
Current: 40
The Colts kept most of the game close against the Jaguars last week. Meanwhile, the Texans’ 25-9 loss to the Ravens was closer than the score might indicate. Houston’s defense played well, but their offense struggled mightily. Yet, they get a much easier matchup against the Colts defense this week.
NFL Pick and Prediction: Lean Texans ML (-105)
Kansas City Chiefs vs. Jacksonville Jaguars Odds
- Spread
Opening: Chiefs -3
Current: Chiefs -3 - Moneyline
Opening: Chiefs -144, Jaguars +122
Current: Chiefs -162, Jaguars +136 - Total
Opening: 51.5
Current: 51
I bet this as soon as the line was briefly at Kansas City -2.5 earlier this week. Patrick Mahomes and the Chiefs don’t cover large spreads, but they’re very profitable as short favorites. In his career, Mahomes is 18-6-1 ATS as a favorite of less than three points.
MORE: 2023 NFL MVP Odds — Tua Tagovailoa New Co-Favorite with Patrick Mahomes
The Chiefs should also be getting both Travis Kelce and Chris Jones back this week. If not for Kadarius Toney, they probably would’ve won last week, and the narrative would be a whole lot different.
The biggest weakness for this Jaguars team is their defense, which wasn’t tested against a poor Colts offense last week. Now they’re hosting Mahomes.
NFL Pick and Prediction: Chiefs -2.5 (-118) placed earlier this week
Las Vegas Raiders vs. Buffalo Bills Odds
- Spread
Opening: Bills -9.5
Current: Bills -8.5 - Moneyline
Opening: Raiders +330, Bills -425
Current: Raiders +300, Bills -380 - Total
Opening: 48
Current: 46.5
There’s no way Josh Allen will play as poorly as he did last week, right?
The betting lines are dropping in the Raiders’ direction after two polar opposite performances from these two teams last week. I would like to buy low on the Bills and sell high on the Raiders after Week 1, but the spread is sort of in a dead zone right now. I’m going to wait and see on this one.
NFL Pick and Prediction: Pass for now, will keep an eye on the best Bills line
San Francisco 49ers vs. Los Angeles Rams Odds
- Spread
Opening: 49ers -7
Current: 49ers -7.5 - Moneyline
Opening: 49ers -320, Rams +260
Current: 49ers -345, Rams +275 - Total
Opening: 43.5
Current: 44.5
Both teams had very impressive wins last week, each winning by double digits on the road, with the Rams pulling off a big upset in Seattle.
The 49ers might’ve looked like the best team in the NFL last week. Brock Purdy looked better than ever coming off his elbow injury, and their defense wreaked havoc on the Steelers.
Kyle Shanahan has owned Sean McVay in this rivalry. The 49ers under Shanahan are 10-3 ATS versus the Rams in the regular season, including 7-0 since 2020. L.A. might be better than we thought they were, but I think San Francisco’s performance last week was much more real in comparison.
NFL Pick and Prediction: Lean 49ers -7.5 (-112)
New York Giants vs. Arizona Cardinals Odds
- Spread
Opening: Giants -5
Current: Giants -5.5 - Moneyline
Opening: Giants -210, Cardinals +176
Current: Giants -218, Cardinals +180 - Total
Opening: 39.5
Current: 40
Everything that could have gone wrong did go wrong for the Giants in their 40-0 loss to the Cowboys on Sunday Night Football. The Cardinals, on the other hand, kept things close against the Commanders. Are we ready to say they aren’t as bad as we expected them to be after one game? Definitely not.
The Giants couldn’t protect Daniel Jones against the Cowboys’ pass rush last week. This week, they go against perhaps the weakest pass rush in the NFL. I expect them to bounce back.
NFL Pick and Prediction: Lean Giants -5.5 (-110)
New York Jets vs. Dallas Cowboys Odds
- Spread
Opening: Cowboys -3
Current: Cowboys -9 - Moneyline
Opening: Jets +130, Cowboys -154
Current: Jets +310, Cowboys -395 - Total
Opening: 45.5
Current: 39
We all know that these betting lines have moved because of Aaron Rodgers’ injury. I was debating taking Cowboys (-3) before Monday night because of the mismatch between Dallas’ pass rush against the Jets’ offensive line, but I didn’t take it. Oh well.
This is a matchup between perhaps the two best defenses in the NFL. I can’t see Zach Wilson having any success against the Cowboys’ defense, but are we sure Dak Prescott won’t have similar struggles against an equally impressive Jets defense?
I would take the under, but I’m worried about turnovers from both quarterbacks in this one, especially Wilson.
NFL Pick and Prediction: Pass for now
Washington Commanders vs. Denver Broncos Odds
- Spread
Opening: Broncos -3.5
Current: Broncos -3.5 - Moneyline
Opening: Commanders +160, Broncos -190
Current: Commanders +145, Broncos -175 - Total
Opening: 40
Current: 38.5
Russell Wilson was cooking in the first half of last week, but then Denver’s offense stalled for the rest of the game, scoring just three points in the second half. Jimmy Garoppolo had a solid day against this defense, but now they go against the much-less experienced QB in Sam Howell.
In his second career start, Howell mostly struggled against a Cardinals defense that was expected to be the most QB-friendly unit in the NFL. This week in Denver, he has a much bigger challenge at hand.
NFL Pick and Prediction: Lean Broncos -3.5 (-105)
Miami Dolphins vs. New England Patriots Odds
- Spread
Opening: Dolphins -2
Current: Dolphins -2.5 - Moneyline
Opening: Dolphins -130, Patriots +110
Current: Dolphins -142, Patriots +120 - Total
Opening: 45.5
Current: 46.5
This line moved up half a point, and that’s not surprising to see after how well the Dolphins played last week. Still, the Patriots were far from unimpressive in their 25-20 loss against the Eagles.
It’s scary to fade this Dolphins offense, especially after the performances from Tua Tagovailoa and Tyreek Hill last week, but it’s time to zag. They will be going against a very impressive Patriots defense this week, and we’re getting a little value right now as the total has already moved up an entire point.
NFL Pick and Prediction: Lean Under 46.5 (-110)
New Orleans Saints vs. Carolina Panthers Odds
- Spread
Opening: Saints -2.5
Current: Saints -3 - Moneyline
Opening: Saints -138, Panthers +118
Current: Saints -166, Panthers +140 - Total
Opening: 41.5
Current: 40.5
The spread going up a half-point is no surprise after watching these two teams play last week. Carolina’s offense struggled mightily against Atlanta, and they will be going against an even better New Orleans defense this week.
I missed the boat on getting the Saints at a key number at -2.5, but for the moment, I still like them on the spread in this spot, even on the road.
NFL Pick and Prediction: Lean Saints -3 (-115)
Cleveland Browns vs. Pittsburgh Steelers Odds
- Spread
Opening: Browns -1
Current: Browns -2 - Moneyline
Opening: Browns -116, Steelers -102
Current: Browns -125, Steelers +105 - Total
Opening: 42.5
Current: 39.5
My strategy for Week 2 is typically to fade the overreactions from Week 1, so I initially liked the Steelers in a bounce-back spot here. However, the more I think about it, the less I like this matchup for them.
Pittsburgh’s offense struggled terribly against San Francisco and will be going against a Browns unit that was very impressive against the Bengals last week.
This spread has gone up a point as I’m sure money is flowing in on the Browns. And WR Diontae Johnson will be out, as he is expected to miss a few weeks due to a hamstring injury. I won on the Browns last week, and I’ll be running it back.
NFL Pick and Prediction: Browns -2 (-110)