The NFL Week 10 odds are centered around some marquee matchups among playoff teams and a monster spread that is going to require some creativity when betting.
How are we using these trends? The PFN Betting Podcast runs through every single game as we head into the weekend!
NFL Week 10 Odds and Betting Trends
All odds are from DraftKings Sportsbook and trends from Inside Edge.
Carolina Panthers vs. Chicago Bears Odds
-
- Spread
Bears -3.5 - Moneyline
Panthers +145, Bears -175 - Total
40
- Spread
The Panthers are just 4-8 ATS when playing on the road since the beginning of last season.
Overs are 8-2 in Chicago’s past 10 games against a bottom-10 run defense. Carolina is currently allowing the eighth-most yards per game through nine weeks.
Indianapolis Colts vs. New England Patriots Odds
-
- Spread
Colts -1.5 - Moneyline
Colts -122, Patriots +102 - Total
43.5
- Spread
The Colts are just 1-5-1 outright when favored since the beginning of last season.
Meanwhile, the Patriots are 3-9 ATS since 2021 against top 10 rushing offenses.
Houston Texans vs. Cincinnati Bengals Odds
-
- Spread
Bengals -7 - Moneyline
Texans +270, Bengals -340 - Total
46.5
- Spread
Unders are 14-7 in Houston road games since the beginning of 2021.
Buying the C.J. Stroud-led Texans as a top-10 pass offense after the record-setting Week 9? The Bengals are 6-2 ATS in their past eight against such opponents.
New Orleans Saints vs. Minnesota Vikings Odds
-
- Spread
Saints -2.5 - Moneyline
Saints -135, Vikings +114 - Total
41.5
- Spread
Unders are 10-3 since the beginning of last season when the Vikings are on the road.
The Saints rank eighth in yards per play allowed, and the Vikings have seen 10 of their past 15 games against a top-10 defense go over the number.
Green Bay Packers vs. Pittsburgh Steelers Odds
-
- Spread
Steelers -3 - Moneyline
Packers +136, Steelers -162 - Total
37.5
- Spread
Overs are 6-3 following a Packers win since the beginning of last season.
Unders are 17-11 since 2021 in games where the Steelers are underdogs.
Tennessee Titans vs. Tampa Bay Buccaneers Odds
-
- Spread
Buccaneers -1 - Moneyline
Titans -105, Buccaneers -115 - Total
38.5
- Spread
Under tickets have cashed in six of Tennessee’s past eight games in warm weather. The expected kickoff temperature is currently 80 degrees.
MORE: NFL Awards Leaders — Betting Favorites at the Halfway Point of the Season
The Bucs are the worst ATS home team since the beginning of last season at 2-9.
San Francisco 49ers vs. Jacksonville Jaguars Odds
-
- Spread
49ers -3 - Moneyline
49ers -166, Jaguars +140 - Total
45
- Spread
Unders are 8-4 since 2021, following a 49ers loss. They lost three straight prior to the Week 9 bye, scoring exactly 17 points in all three games.
Unders have come through in nine of Jacksonville’s past 13 games against top 10 defenses.
Cleveland Browns vs. Baltimore Ravens Odds
-
- Spread
Ravens -6 - Moneyline
Browns +200, Ravens -245 - Total
37.5
- Spread
Since 2021, the Browns are 6-9 ATS in divisional games, with unders holding a 9-5-1 record in those contests.
Unders are 10-2 when the Ravens have hosted a game since the beginning of last season.
Atlanta Falcons vs. Arizona Cardinals Odds
-
- Spread
Falcons -2 - Moneyline
Falcons -120, Cardinals +100 - Total
42
- Spread
Unders are 7-4 in Atlanta’s past 11 road games.
The Cardinals are a league-worst 2-10 ATS at home since the beginning of last season.
Detroit Lions vs. Los Angeles Chargers Odds
-
- Spread
Lions -1.5 - Moneyline
Lions -122, Chargers +102 - Total
48.5
- Spread
Since 2021, the Lions are 11-3 ATS against top-10 passing offenses.
Unders are 8-4 in Chargers home games since the beginning of last season.
New York Giants vs. Dallas Cowboys Odds
-
- Spread
Cowboys -16 - Moneyline
Giants +700, Cowboys -1100 - Total
39
- Spread
Unders improved to 27-8-1 since the beginning of 2021 when the Giants were an underdog last week against QB Aiden O’Connell and the Raiders (30-6 final with a 37.5 point total).
Dallas has won 12 of the past 13 meetings with New York. Seven of those wins came by at least 15 points.
Washington Commanders vs. Seattle Seahawks Odds
-
- Spread
Seahawks -6 - Moneyline
Commanders +215, Seahawks -265 - Total
45.5
- Spread
Unders are 12-4 in Washington’s last 16 games against a bottom-10 passing offense. Geno Smith’s passer rating is down 14.5 points from last season, and he has just nine touchdown passes in his eight games.
The Seahawks are a bottom-10 team in terms of outright win percentage when favored since the start of 2021 (55%).
New York Jets vs. Las Vegas Raiders Odds
-
- Spread
Jets -2 - Moneyline
Jets -125, Raiders +105 - Total
35.5
- Spread
Unders are 18-7 (72%) in Jets games since the beginning of last season (second-highest hit rate).
The Raiders are 7-4 ATS in their past 11 games when facing a top-10 defense.
Denver Broncos vs. Buffalo Bills Odds
-
- Spread
Bills -7.5 - Moneyline
Broncos +295, Bills -375 - Total
47
- Spread
The Broncos haven’t played a road game in a month. They are 6-12 ATS on the road since the start of 2021, the second-worst mark in the NFL over that stretch.
The Bills are perfect this season and have won 11 of their past 13 games following a loss.
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