Week 15 betting lines for each NFL game are set . . . for now. As we know, things can and often will change — sometimes dramatically based on injuries, weather, and once-a-century locust infestations.
The following betting odds are for picks against the spread, moneylines, and over/unders based on FanDuel Sportsbook.
Early NFL Week 15 Odds
Each week of the NFL season features the expected, the moderately unexpected, and the completely unexpected. When betting on point spreads and moneylines, we need to focus on the first two outcomes. With that in mind, here are our assessments of each game’s optimal betting options.
Seattle Seahawks vs. San Francisco 49ers | Thursday
- Moneyline: Seahawks (+156) / 49ers (-186)
- Spread: 49ers (-3.5)
- Over/Under: 43.5
Deebo Samuel’s ankle injury might keep him out for a few weeks. On a team as defensively stout as the 49ers, that might not matter in this favorable home tilt.
Seattle looked overwhelmed in a shocking home defeat to the Panthers. If they can get Kenneth Walker III back, they’ve got a shot at keeping this one within five points. But a victory seems farfetched as long as Christian McCaffrey continues to tear up defenses.
I’m taking the Niners to win and cover, as well as the over on points.
Minnesota Vikings vs. Indianapolis Colts | Saturday
- Moneyline: Vikings (-210) / Colts (+176)
- Spread: Vikings (-4.5)
- Over/Under: 47.5
If the 4-8-1 Colts lose, their season effectively will be over, despite playing in the relatively easy AFC South. That doesn’t mean they’ll keep this one close. I expect them to play it safe for as long as possible, however. That might mean a heavy load for Jonathan Taylor.
Compared to this past week’s offensive explosion against the defensively limited Lions, Minnesota will find it tougher to move the ball versus Indy. But the odds assume at least one Matt Ryan blunder — perhaps an ill-advised pass over the middle at his own seven-yard line.
Cleveland Browns vs. Baltimore Ravens | Saturday
- Moneyline: Browns (-142) / Ravens (+120)
- Spread: Browns (-3)
- Over/Under: 38.5
In another universe, this would be a thrilling contest between two playoff contenders. Instead, if Tyler Huntley can’t take the field, the 9-4 Ravens will be forced to start a third-string QB in a critical late-season matchup for the second consecutive season.
While Deshaun Watson has looked rusty, as expected, the 5-8 Browns still somewhat control their postseason destiny. A moderately manageable remaining schedule could elevate them to 9-8.
MORE: Early NFL Week 15 Predictions and Picks Against the Spread
Notably, Nick Chubb is averaging only 3.5 yards per carry in his last four contests. Is he slowing down? Are defenses forcing the Browns to win through the air? A little of both?
The Ravens’ defense has been elite against the run. It’s a tough combination, and it might force Watson to produce his best showing since his return.
Buffalo Bills vs. Miami Dolphins | Saturday
- Moneyline: Bills (-330) / Dolphins (+265)
- Spread: Bills (-7)
- Over/Under: 42.5
Knowing that Miami beat Buffalo earlier this season, the lines for this rematch might seem a bit odd. But with Jeff Wilson Jr. hurt, Jaylen Waddle scuffling, and the Bills playing some of their best football on offense and defense, the lines make sense to me.
I just checked Weather.com. Rain and snow are possible Thursday and Friday, with snow showers in the forecast for Saturday. The Dolphins thrive on yards after the catch. In tough conditions, they might have trouble capitalizing.
New Orleans Saints vs. Atlanta Falcons | Sunday
- Moneyline: Saints (-196) / Falcons (+164)
- Spread: Saints (-3.5)
- Over/Under: 42.5
Would we be surprised if the Falcons win in Desmond Ridder’s NFL debut? Of course not. He’s a legitimate future long-term starting QB, especially on a seemingly ascending team.
But going on the road against the Saints isn’t an ideal career opener, especially with so few above-replacement-level playmakers at his disposal. Depending on the volume of the Ridder buzz this week, we might see the betting lines shift. If you want to track which betting site has the most favorable lines in real time, check out the handy-dandy Pikkit app.
Chicago Bears vs. Philadelphia Eagles | Sunday
- Moneyline: Bears (+320) / Eagles (-405)
- Spread: Bears (+8.5)
- Over/Under: 48.5
Chicago has had great chances to prevail in several of their losses. Justin Fields’ relative inexperience — and more to the point, his league-worst receiving corps — have been the difference.
But if not for Fields, this point spread might be 15 or more. That’s the power of the Bears’ franchise QB, and it also reflects some doubts about Philly’s once heralded defense.
New York Jets vs. Detroit Lions | Sunday
- Moneyline: Jets (-116) / Lions (-102)
- Spread: Jets (-1.5)
- Over/Under: 44.5
Mike White (ribs) left Sunday’s game and went to get checked out at the hospital. All good on that front. But we just don’t know (as of Monday) whether he or Joe Flacco — or Zach Wilson — will start in Week 15.
This line favored the Jets by three points on Sunday. Funny what a New York loss and Detroit victory can do to sway opinions.
MORE: Lions Prove Playoff Potential With Win Over Vikings
Can the Jets’ D to slow the Lions? Can Detroit’s vulnerable defense stack up against Garrett Wilson and Elijah Moore?
Carolina Panthers vs. Pittsburgh Steelers | Sunday
- Moneyline: Panthers (-134) / Steelers (+114)
- Spread: Panthers (-1.5)
- Over/Under: 38.5
Almost a mirror image of the Jets-Lions tilt. Surprisingly, Carolina has enough talent to prevail, especially if Kenny Pickett (concussion) can’t get cleared in time. The Panthers still have a shot at the postseason, and even if DJ Moore remains hobbled, the point spread suggests they can win the field-position battle, thanks to an (arguably) more dynamic backfield and better defense.
Jacksonville Jaguars vs. Dallas Cowboys | Sunday
- Moneyline: Jaguars (+188) / Cowboys (-225)
- Spread: Jaguars (+4.5)
- Over/Under: 47.5
As if we needed reminding, almost any NFL team can beat almost any other NFL team. Houston nearly upended the Cowboys in Dallas, while Jacksonville stomped on the division-leading Titans in Tennessee.
Line setters expect a relatively high-scoring game, featuring two seemingly high-functioning offenses and one (often) very good defense. The Jags can still win the AFC South. They’ll throw everything at Dallas, literally and figuratively. This could be the most thrilling game of the week, with the result not decided until the final minute.
Houston Texans vs. Kansas City Chiefs | Sunday
- Moneyline: Texans (+610) / Chiefs (-900)
- Spread: Texans (+14)
- Over/Under: 48.5
Patrick Mahomes was both brilliant and atrocious on Sunday, as Denver almost pulled off a shocking upset/comeback. The Chiefs’ offense will look more playoff ready against Houston. The point spread is almost daring bettors to pick the Texans, and if Brandin Cooks and/or Nico Collins return, it might move down a couple points.
Denver Broncos vs. Arizona Cardinals | Sunday
- Moneyline: Broncos (-102) / Cardinals (-116)
- Spread: Cardinals (-1.5)
- Over/Under: 38.5
On Sunday, Denver was favored by a point. After Monday’s game, the spread could flip again.
This is truly a toss-up, and it might hinge on whether Russell Wilson can start, or if Brett Rypien (along with Latavius Murray) will lead the severely undermanned Broncos to a near-certain defeat. There’s a lot of wait-and-see to this contest.
Las Vegas Raiders vs. New England Patriots | Sunday
- Moneyline: Raiders (-108) / Patriots (-108)
- Spread: Patriots (+1.5)
- Over/Under: 44.5
The Patriots have more to play for and a much stronger defense, while the Raiders arguably have the two best playmakers in this game. Davante Adams and Josh Jacobs hold the keys to Vegas’s fading postseason hopes. But as a big-play team, they’re expected to keep this one competitive, if not win outright.
Los Angeles Chargers vs. Tennessee Titans | Sunday
- Moneyline: Chargers (-164) / Titans (+138)
- Spread: Chargers (-3)
- Over/Under: 46.5
Across nearly every metric, Austin Ekeler has struggled on the ground. But that won’t matter in this contest, because, assuredly, the Chargers won’t try to test the Titans’ elite run defense.
Instead, L.A. will try to dominate through the air, forcing the Titans to throw to keep pace. Can Derrick Henry slow this game down? That’s the huge question entering a contest that, according to the line setters, advantages the Chargers not necessarily because they’re better, but because they’re at home
Tampa Bay Buccaneers vs. Cincinnati Bengals | Sunday
- Moneyline: Bengals (-190) / Buccaneers (+160)
- Spread: Bengals (-3.5)
- Over/Under: 42.5
When was the last time the two most recent Super Bowl champs played so poorly for so much of the season? We can blame the Bucs’ and Rams’ woes on injuries, and certainly, that’s part of it. But both teams have catastrophic shortcomings: legendary post-prime QBs.
MORE: Potential Landing Spots for Tom Brady in 24th NFL Season
Tom Brady will step aside for no one, and who could blame him? But he’s not the same player he once was, and playing behind a depleted offensive line has exposed/exacerbated his deficiencies.
That’s largely why Cincy is favored on the road. And the point spread could change depending on Tee Higgins’ and/or Hayden Hurst’s return.
Washington Commanders vs. New York Giants | Sunday
- Moneyline: Commanders (-200) / Giants (+168)
- Spread: Commanders (-3.5)
- Over/Under: 40.5
Why weren’t the Giants buyers before the trade deadline? My theory at the time was that they knew their 6-1 start wasn’t sustainable. A brutal December/January schedule would almost certainly make them no better than a Wild Card, and trading for a receiver or some other upgrade wouldn’t be enough.
Three weeks ago, I didn’t see how they could reach the playoffs, despite being 7-3. After an ugly tie against Washington two weeks ago, they are underdogs for good reasons heading into this rematch.
Green Bay Packers vs. Los Angeles Rams | Monday
- Moneyline: Packers (-350) / Rams (+280)
- Spread: Packers (-7.5)
- Over/Under: 39.5
As heroically as Baker Mayfield played down the stretch last Thursday, that was against the Raiders. The line setters aren’t buying it against a tougher Green Bay’ secondary.
The Packers somehow remain in postseason contention at 5-8, aided by Seattle’s shocking home loss to Carolina. There’s a strong sense in the market that the Packers will deliver at home. The big question is whether Mayfield has found a true home, or if last week was a fluke.