The Buffalo Bills will face the Indianapolis Colts in Week 10. Here’s the latest fantasy football news and advice to help you with your lineups this week and moving forward, especially regarding RB James Cook.
Is James Cook Playing in Week 10?
Cook is not listed on the injury report this week, so barring any setbacks, he is on track to play this weekend.
We’ll continue to monitor the Bills’ injury report. You can also visit and bookmark our NFL Injury Tracker and Fantasy News Tracker for the latest updates.
Should You Start or Sit James Cook in Week 10?
James Cook opened the season with a pair of games over 70 rushing yards — he’s reached 45 rushing yards in just two of six games since. He saved your day with a season-high five receptions against the Dolphins on Sunday, but that’s a dangerous way to live.
As scary as that profile is, I’m not the least bit nervous about this week against a Colts defense that ranks 27th against running backs after contact and 29th in RB rushing yards per game. Through nine weeks, Cook is the third most efficient running back when compared against expectations (Derrick Henry leading the charge with Jahmyr Gibbs second) and grades out as an RB1 for me this week.
Are you looking for start/sit advice for other players in your lineup? Read our Week 10 Fantasy Start-Sit Advice Cheat Sheet for every fantasy-relevant player in every game.
James Cook’s Fantasy Points Projection in Week 10
As of Sunday, Cook is projected to score 15.3 fantasy points in PPR formats. This includes 16.3 rushing attempts for 84.7 yards and 0.2 touchdowns. It also includes 1.4 receptions for 30 yards and 0.2 touchdowns.
Check out the free PFN Fantasy Start-Sit Optimizer for the latest projections and advice for your lineups this week.
PFN Insight on the Colts’ Defense
The Indianapolis Colts fell back into their own ways after a couple of good weeks in Weeks 7 and 8. For the majority of the season they have been a league-average-or-worse defense, but briefly jumped up inside the top 10 for those two games. That improvement over a two-week span may have been part of their quarterback decision if they felt that the defense was reaching a point where it could give them stability.
Unfortunately, that has not been the case, as they struggled against the Vikings on Sunday Night Football. Despite investment in their pass rush, they struggle to get pressure without blitzing, and their pass defense is inside the lower half of the teams in the league. A 43.7% third-down conversion rate is also a concern, ranking as the ninth-lowest in the league.
Do you want more insight on all other defensive units across the NFL? Head over to our PFN Defense+ Rankings for analysis on all 32 teams.
James Cook’s Week 10 Fantasy Ranking
Our Weekly Consensus PPR Rankings are below — both positional and overall. They were last updated at 7:25 AM ET on Sunday, December 29. If you're in a Superflex league, make sure you check out our Weekly Consensus Superflex Rankings.
Week 17 RB PPR Rankings
1) Saquon Barkley | PHI (vs. DAL)
2) Jahmyr Gibbs | DET (at SF)
3) Derrick Henry | BAL (at HOU)
4) Bijan Robinson | ATL (at WAS)
5) Josh Jacobs | GB (at MIN)
6) Jonathan Taylor | IND (at NYG)
7) Chase Brown | CIN (vs. DEN)
8) Kyren Williams | LAR (vs. ARI)
9) De'Von Achane | MIA (at CLE)
10) Bucky Irving | TB (vs. CAR)
11) James Conner | ARI (at LAR)
12) James Cook | BUF (vs. NYJ)
13) Tyjae Spears | TEN (at JAX)
14) Breece Hall | NYJ (at BUF)
15) Joe Mixon | HOU (vs. BAL)
16) Zach Charbonnet | SEA (at CHI)
17) Aaron Jones | MIN (vs. GB)
18) Jerome Ford | CLE (vs. MIA)
19) Brian Robinson Jr. | WAS (vs. ATL)
20) D'Andre Swift | CHI (vs. SEA)
21) Rico Dowdle | DAL (at PHI)
22) Tyrone Tracy Jr. | NYG (vs. IND)
23) Isaac Guerendo | SF (vs. DET)
24) Rhamondre Stevenson | NE (vs. LAC)
25) Rachaad White | TB (vs. CAR)
26) J.K. Dobbins | LAC (at NE)
27) Alexander Mattison | LV (at NO)
28) Jaylen Warren | PIT (vs. KC)
29) Isiah Pacheco | KC (at PIT)
30) Kimani Vidal | LAC (at NE)
31) Tank Bigsby | JAX (vs. TEN)
32) Javonte Williams | DEN (at CIN)
33) Kendre Miller | NO (vs. LV)
34) Najee Harris | PIT (vs. KC)
35) Travis Etienne Jr. | JAX (vs. TEN)
36) Ameer Abdullah | LV (at NO)
37) Kareem Hunt | KC (at PIT)
38) Devin Singletary | NYG (vs. IND)
39) Tyler Allgeier | ATL (at WAS)
40) Audric Estimé | DEN (at CIN)
41) Ray Davis | BUF (vs. NYJ)
42) Raheem Mostert | MIA (at CLE)
43) Antonio Gibson | NE (vs. LAC)
44) Kenneth Gainwell | PHI (vs. DAL)
45) Craig Reynolds | DET (at SF)
46) Cam Akers | MIN (vs. GB)
47) Ty Johnson | BUF (vs. NYJ)
48) Blake Corum | LAR (vs. ARI)
49) Roschon Johnson | CHI (vs. SEA)
50) Braelon Allen | NYJ (at BUF)
51) Patrick Taylor Jr. | SF (vs. DET)
52) Jeremy McNichols | WAS (vs. ATL)
53) Isaiah Davis | NYJ (at BUF)
54) Jaleel McLaughlin | DEN (at CIN)
55) D'Onta Foreman | CLE (vs. MIA)
56) Jamaal Williams | NO (vs. LV)
57) Cordarrelle Patterson | PIT (vs. KC)
58) Emanuel Wilson | GB (at MIN)
59) DeeJay Dallas | ARI (at LAR)
60) Chris Brooks | GB (at MIN)
61) Pierre Strong Jr. | CLE (vs. MIA)
62) Ke'Shawn Vaughn | SF (vs. DET)
63) Keaton Mitchell | BAL (at HOU)
64) Trey Benson | ARI (at LAR)
65) Raheem Blackshear | CAR (at TB)
66) Sean Tucker | TB (vs. CAR)
67) Israel Abanikanda | SF (vs. DET)
68) Michael Carter | ARI (at LAR)
69) Samaje Perine | KC (at PIT)
70) Ezekiel Elliott | DAL (at PHI)
71) Mike Boone | CAR (at TB)
72) Khalil Herbert | CIN (vs. DEN)
73) Dare Ogunbowale | HOU (vs. BAL)
74) Jaylen Wright | MIA (at CLE)
75) Kyle Juszczyk | SF (vs. DET)
76) Trey Sermon | IND (at NYG)
77) Chris Rodriguez Jr. | WAS (vs. ATL)
78) Sione Vaki | DET (at SF)
79) Hunter Luepke | DAL (at PHI)
80) Dameon Pierce | HOU (vs. BAL)
81) Alec Ingold | MIA (at CLE)
82) Tyler Goodson | IND (at NYG)
83) Hassan Haskins | LAC (at NE)
84) Kenny McIntosh | SEA (at CHI)
85) Jordan Mims | NO (vs. LV)
86) Rasheen Ali | BAL (at HOU)
87) Ty Chandler | MIN (vs. GB)
88) C.J. Ham | MIN (vs. GB)
89) Michael Burton | DEN (at CIN)
90) Julius Chestnut | TEN (at JAX)
91) Eric Gray | NYG (vs. IND)
92) Dylan Laube | LV (at NO)
93) Adam Prentice | NO (vs. LV)
94) Patrick Ricard | BAL (at HOU)
95) Carson Steele | KC (at PIT)
96) Keilan Robinson | JAX (vs. TEN)
97) Darrynton Evans | BUF (vs. NYJ)
98) Blake Watson | DEN (at CIN)
99) Clyde Edwards-Helaire | KC (at PIT)
Buffalo Bills at Indianapolis Colts Insights
Buffalo Bills
Team: Buffalo is seeking a fifth straight win – they haven’t had a five-game win streak in the first 10 weeks of a season during the 2000s.
QB: In eight games this season, Josh Allen has been held without a deep touchdown pass seven times (on Sunday against the Dolphins, he attempted just three deep passes (five games prior: 8.6 deep pass attempts per game).
Offense: The Bills are turning the ball over just 0.44 times per game, the second-fewest in the NFL and down from 1.65 times per game a season ago.
Defense: Dink-and-dunk: opponents average a league-low 6.2 air yards per throw against Buffalo this season.
Fantasy: James Cook opened the season with a pair of games over 70 rushing yards – he’s reached 45 rushing yards in just two of six games since. He saved your day with a season-high five receptions against the Dolphins on Sunday, but that’s a dangerous way to live.
Betting: Under tickets have come through in five of Buffalo’s past six road games, but don’t mistake that for sportsbooks struggling to handicap this team – all of those games finished within three points of the closing total.
Indianapolis Colts
Team: Indianapolis’s offense has only been on the field for 25:41 per game this season, which is 100 seconds less per game than any other offense in the league.
QB: Over the past four weeks, Joe Flacco and Anthony Richardson have made two starts apiece.
- Flacco: 5.7 yards per attempt with as many touchdowns as interceptions
- Richardson: 5.4 yards per attempt with as many touchdowns as interceptions
Offense: The Colts rank 30th in offensive success rate (ahead of only the Chargers and Browns).
Defense: After a brutal start to the season, the Colts own the second-best rush defense by EPA (first: Chargers).
Fantasy: Josh Downs has a 36.5% on-field target share from Joe Flacco this season (Michael Pittman: 19%, Alec Pierce: 10.3%).
Betting: The Colts are 4-0 ATS at home this season (they haven’t had a winning ATS season in front of their home fans since 2017).