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    Early NFL Week 15 Predictions and Picks Against the Spread: Impact of Injuries to Justin Herbert, Justin Jefferson, and C.J. Stroud

    How do injuries to Justin Herbert, Justin Jefferson, and C.J. Stroud impact NFL betting lines? We break it down in our NFL Week 15 predictions.

    Although we have a Monday Night Football doubleheader remaining, we’re moving on to Week 15 and the NFL betting lines for next week. This week’s NFL odds feature two double-digit favorites and a home underdog getting almost 10 points. As I do every week, I give my early NFL picks after an initial review of the lines. So with that being said, here are my early NFL Week 15 predictions.

    NFL Week 15 Predictions and Picks

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    Los Angeles Chargers vs. Las Vegas Raiders Odds

    • Spread
      Raiders -3
    • Moneyline
      Chargers +130, Raiders -150
    • Total
      34.5

    Just when you thought the Chargers’ season couldn’t get worse, it looks like they’ll be without Justin Herbert for their remaining four games, and their playoff hopes are almost certainly dead.

    The Raiders’ offense put up a pathetic offensive performance on Sunday, but they have been playing very stout defensively since Antonio Pierce became interim head coach. Against a backup quarterback at home, I like that to continue.

    Pick: Under 34.5

    Minnesota Vikings vs. Cincinnati Bengals Odds

    • Spread
      Bengals -4
    • Moneyline
      Vikings +175, Bengals -210
    • Total
      39.5

    Jake Browning continues to impress, but he did leave Sunday’s game with an injury.

    The Vikings’ offense is a mess, as Joshua Dobbs was benched in Sunday’s 3-0 win over the Raiders, and they lost Justin Jefferson to injury … again.

    MORE: PFN’s FREE NFL Playoff Predictor

    As bad as Minnesota’s offense is, their defense was lights out on Sunday. I’m going to put trust into this unit delivering again.

    Pick: Under 39.5

    Pittsburgh Steelers vs. Indianapolis Colts Odds

    • Spread
      Colts -2.5
    • Moneyline
      Steelers +115, Colts -135
    • Total
      42.5

    The Steelers are one of the last teams I want to bet on right now. You would think after two consecutive home losses to the Arizona Cardinals and New England Patriots that this spread would be higher, but the Colts are giving under a field goal at home. Might be the chalky play, but that’s where I’m leaning for now.

    Pick: Colts -2.5

    Denver Broncos vs. Detroit Lions Odds

    • Spread
      Lions -4
    • Moneyline
      Broncos +165, Lions -195
    • Total
      46.5

    These are two teams heading in opposite directions, but I like this as a bounce-back spot for Detroit at home. Denver continues to get lucky during its hot streak; meanwhile, the Lions are due for a get-right game, and their offense should play much better at home than they did in Chicago on Sunday.

    Pick: Lions -4

    Tampa Bay Buccaneers vs. Green Bay Packers Odds

    • Spread
      Packers -3.5
    • Moneyline
      Buccaneers +155, Packers -185
    • Total
      42.5

    We’ve seen how bad this Buccaneers’ pass defense has been in recent weeks, as they even allowed Desmond Ridder to throw for 347 yards. With how Jordan Love has been playing recently, he should have a field day against this defense at home. Against non-divisional opponents this season, the Buccaneers are 1-5 on the road.

    Pick: Packers -3.5

    New York Giants vs. New Orleans Saints Odds

    • Spread
      Saints -6
    • Moneyline
      Giants +225, Saints -275
    • Total
      36.5

    I’m not going to have any more faith in the Saints just because they beat up a terrible Carolina Panthers team on Sunday. Even though they won by 22 points, the Panthers generated nearly 100 more yards of offense. I’m not sure, even at home against a bad Giants team, they can cover this many points as a favorite two weeks in a row.

    Pick: Giants +6

    Atlanta Falcons vs. Carolina Panthers Odds

    • Spread
      Falcons -3
    • Moneyline
      Falcons -155, Panthers +135
    • Total
      34.5

    I’m probably the only person in America who is betting on the Panthers for the third week in a row. With how poorly Ridder has played on the road this season, it seems like a good opportunity to fade him and the Falcons giving three points in Carolina. The Panthers, with Jaycee Horn back in the lineup, have a better defense than the unit the Falcons put up 25 points against on Sunday at home.

    Pick: Panthers +3

    Houston Texans vs. Tennessee Titans Odds

    • Spread
      Titans -2.5
    • Moneyline
      Texans +110, Titans -130
    • Total
      37.5

    The look-ahead line for this was Texans -3.5, but now C.J. Stroud is in concussion protocol. The five-point swing illustrates how valuable Stroud is to this team, and even before Stroud’s injury, the Texans were starting to get extremely banged up on offense.

    MORE: NFL Against the Spread Standings

    I’m not sure Davis Mills can attack this weak Titans pass defense, and I have little faith in the Texans’ running game in this matchup either.

    Pick: Under 37.5

    New York Jets vs. Miami Dolphins Odds

    • Spread
      Dolphins -8.5
    • Moneyline
      Jets +360, Dolphins -450
    • Total
      39.5

    Zach Wilson had maybe the best game of his career on Sunday, as he threw for over 300 yards and two touchdowns in the Jets’ 30-6 win over the Houston Texans. But let’s not let this one-game sample size change our perception of Wilson.

    While the Dolphins did have an embarrassing loss on Monday Night Football, they were without Tyreek Hill for nearly half of the game. If he’s a full go for this week, I like their chances of bouncing back in convincing fashion.

    Pick: Dolphins -8.5

    Chicago Bears vs. Cleveland Browns Odds

    • Spread
      Browns -3.5
    • Moneyline
      Bears +150, Browns -175
    • Total
      37.5

    The Bears’ defense might be the most improved unit of the season, and they’re coming off an impressive performance in their 28-13 win over the Lions in which Chicago held Detroit to just 267 total yards. This should be a much bigger test for Joe Flacco, who has exceeded everyone’s expectations in two games as the Browns’ starting quarterback.

    I’m going to continue to ride with the Bears here, who have ascended from not being one of the worst five teams in the league anymore.

    Pick: Bears +3.5

    Kansas City Chiefs vs. New England Patriots Odds

    • Spread
      Chiefs -10
    • Moneyline
      Chiefs -500, Patriots +380
    • Total
      37.5

    This is a lot of points for a home underdog coming off 10 days of rest, but I’m still not sure I want to take the points with the Patriots.

    The Chiefs (incorrectly), feel like they were robbed of a win over the Bills on Sunday with the offsides call on Kadarius Toney negating a go-ahead touchdown, so they should be entering this game with a lot of motivation.

    Patriots had a nice win last week, but going from Mitch Trubisky to Patrick Mahomes will be a major step up in class. Let’s not forget that this is still a very bad football team.

    Pick: Chiefs -10

    Washington Commanders vs. Los Angeles Rams Odds

    • Spread
      Rams -6.5
    • Moneyline
      Commanders +250, Rams -300
    • Total
      48.5

    This is a very favorable matchup for the Rams, as Matthew Stafford, Cooper Kupp, and Puka Nacua should be able to feast on this Commanders pass defense. With the Rams fighting for their playoff lives, I think they take advantage of the league’s worst team at defending the pass.

    Pick: Rams -6.5

    San Francisco 49ers vs. Arizona Cardinals Odds

    • Spread
      49ers -13.5
    • Moneyline
      49ers -900, Cardinals +600
    • Total
      47.5

    Once again, the 49ers’ offense looked unstoppable on Sunday, as they put up 527 yards of offense in their 28-16 win over the Seahawks. It takes a lot of guts to want to fade them at the moment, and even as 14-point road favorites against a division rival, I can’t recommend picking against them.

    Pick: 49ers -13.5

    Dallas Cowboys vs. Buffalo Bills Odds

    • Spread
      Bills -1.5
    • Moneyline
      Cowboys +100, Bills -120
    • Total
      49.5

    The narrative that the Cowboys can’t beat good teams is dead, as they dominated the Eagles in a 33-13 win on Sunday Night Football. The question now is if they can pull it off on the road against a really good Bills team.

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    I picked the Bills on Sunday to beat the Chiefs, and I think this is the beginning of a late-season run for them. Even at 7-6, you could still argue they’re one of the five scariest teams in the NFL, and this game will be the Cowboys’ biggest test in a long time.

    Pick: Bills -1.5

    Baltimore Ravens vs. Jacksonville Jaguars Odds

    • Spread
      Ravens -3.5
    • Moneyline
      Ravens -175, Jaguars +150
    • Total
      43.5

    The Ravens escaped with an overtime win over the Rams on Sunday and are firmly in the mix for the top seed in the AFC. Even though Stafford picked them apart on Sunday, I don’t think this Ravens defense will have two bad performances in a row, even on the road. I’m going to go back to my roots here with a prime time under.

    Pick: Under 43.5

    Philadelphia Eagles vs. Seattle Seahawks Odds

    • Spread
      Eagles -4
    • Moneyline
      Eagles -195, Seahawks +165
    • Total
      48

    The Eagles might not be the team we thought they were when they were 10-1, but their gauntlet is finally past them, as they escaped a five-game stretch against the Cowboys twice, Chiefs, Bills, and 49ers with a 3-2 record. In this game, they finally won’t be at a rest disadvantage either, as they had two games in a row against teams coming off Thursday Night Football games.

    Although they were dominated on both sides of the ball against Dallas, their offense had three flukey fumbles in Cowboys territory. I’m expecting a bounce-back performance for Jalen Hurts and his weapons on Monday Night Football.

    Pick: Eagles -4

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