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    Cardinals vs. Commanders Prediction, Picks, Odds Today: Commanders Face a Big Number To Cover

    It's the first game of a new era in Washington. We break down the odds for Cardinals vs. Commanders, give out a prediction, and more.

    It’s a new era in Washington. We look at the Arizona Cardinals vs. Washington Commanders matchup, give you the betting odds, make a prediction, and more.

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    Cardinals vs. Commanders Betting Lines, Start Time and More

    All odds from DraftKings Sportsbook.

    • Spread: Commanders -7
    • Moneyline: Cardinals (+270); Commanders (-340)
    • Over/Under: 38
    • Game time: 1:00 p.m. ET
    • Location: FedEx Field
    • Channel: FOX

    Game Prediction

    Raise your hand if you predicted during the summer that the Commanders would be favored by the second-largest spread in Week 1.

    Don’t worry, I didn’t have my hand up either.

    In any event, it’s clear that while Washington retooled its offense to try and make some noise in the NFC East, Arizona’s aspirations for this season may be geared more toward the 2024 NFL Draft.

    While Sam Howell enters as the clear-cut No. 1 quarterback in Washington, Arizona’s QB situation is a mess. Kyler Murray is out for at least the first four games after undergoing surgery for a torn ACL. Josh Dobbs appears to be the man taking over for now.

    Washington simply has too many playmakers on the offensive side of the ball, with a solid wide receiver duo of Terry McLaurin and Jahan Dotson, as well as a strong running back combination of Brian Robinson and Antonio Gibson.

    A new owner (Josh Harris), a new quarterback (Howell), and a new OC (Eric Bieniemy) have the Commanders’ fan base fired up for this season. The first step should be taking care of the teams you’re supposed to beat.

    Best Bet: Commanders -7 (-110 at DraftKings SportsBook)

    Place your bet for Cardinals vs. Commanders on the widget below!

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