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    Bills vs. Chiefs Prediction, Picks, Odds Today: It’s Josh Allen vs. Patrick Mahomes One More Time

    Quarterbacks are the headlining act in the Bills vs. Chiefs matchup. We'll give you the odds, break down the game, and make a best bet prediction.

    For NFL fans, the Buffalo Bills vs. Kansas Chiefs is the glamour matchup of Week 14. For the Bills, it’s an opportunity to get themselves right back in the playoff race. The Chiefs, meanwhile, are trying to avoid something that hasn’t occurred in over two years — a second straight loss.

    Bills vs. Chiefs Betting Lines, Start Time, and More

    All odds from DraftKings Sportsbook.

    • Spread: Chiefs -1.5
    • Moneyline: Bills (-102), Chiefs (-118)
    • Over/Under: 49
    • Game time: 4:25 p.m. ET
    • Location: GEHA Field at Arrowhead Stadium
    • Channel: CBS

    Bills vs. Chiefs Prediction

    The Bills and Chiefs has one thing in common this season: both have not looked the same since beating the Miami Dolphins.

    Buffalo is 3-5 since its Week 4 win over the Dolphins, while Kansas City has lost two of three since beating Miami in Week 9.

    As you can imagine, the attention in this contest will focus on the quarterbacks. The Bills’ Josh Allen has faced heavy criticism most of the season for his play and the Bills’ inconsistent performance. But he may have given fans a sign that he is back to his old self in the loss to the Eagles.

    Allen threw for 339 yards and two TD passes, while also rushing for a season-high 81 yards. His 420 combined passing/rushing numbers were easily a season high.

    Meanwhile, fans are waiting to see Patrick Mahomes have that blowout game once, because it has been a while. After throwing for 424 yards and four touchdowns against the Chargers in Week 7 — both season highs — Mahomes has not thrown for 300 yards in any of his last five games, and his touchdown pass-to-interception ratio of 7:4 is hardly impressive.

    It might surprise some people to learn that this Chiefs defense has reached elite status this season. They rank top five in both total defense (fourth) and scoring defense (third), while Buffalo is hardly a liability defensively, ranking 12th in total defense and fifth in scoring defense.

    MORE: NFL Team Over/Under Standings

    The Bills could get tight end Dawson Knox back after he’s been out for five games with a wrist injury. He’s listed as questionable, but if he can play, it would be a boost for the Bills’ offense.

    Kansas City’s injury issues run a little longer than Buffalo. Running back Isiah Pacheco will not play due to a shoulder problem, while offensive tackle Donovan Smith (neck), linebacker Drue Tranquill (concussion), and safety Bryan Cook (ankle) — all starters — are out for Sunday as well.

    From a betting trends standpoint, the Bills are not in a good spot. They are 1-4 vs. the spread away from home and just 2-6 ATS vs. non-divisional opponents.

    The Chiefs, meanwhile, have loved this position all season. They are 3-0 this season against the spread coming off a straight-up loss.

    MORE: PFN’s FREE NFL Playoff Predictor

    Buffalo should be playing this game like it is a playoff elimination-type contest. Furthermore, with games still to come vs. the Cowboys and a rematch at the end of the season with the Dolphins, the Bills may be running out of chances to make a playoff push.

    The Chiefs, however, haven’t been impressive since beating the Dolphins right before their bye week. They’re 1-2 since returning from the bye week, getting held under 20 points in those two losses.

    Last season, Kansas City played 20 games combined between the regular season and playoffs and was held under 20 points in one game. This season, the Chiefs have been held under 20 points five times.

    The over/under is 49 points, and the Chiefs have played in one game that finished with a combined point total of 49 or more — Week 3 vs. the Bears.

    There just won’t be a lot of points in this contest.

    Best Bet: Under 49 points (-112 at DraftKings Sportsbook)

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