The Buffalo Bills will face the San Francisco 49ers in Week 13. Here’s the latest fantasy football news and advice to help you with your lineups this week and moving forward, especially regarding RB James Cook.
Is James Cook Playing in Week 13?
Cook is not listed on the injury report this week, so barring any setbacks, he is on track to play this weekend.
We’ll continue to monitor the Bills’ injury report. You can also visit and bookmark our NFL Injury Tracker and Fantasy News Tracker for the latest updates.
Should You Start or Sit James Cook in Week 13?
James Cook has returned great profits on your investment this summer with six RB1 finishes this season, including in three of his past four games as he trends toward matchup-proof status.
Cook has remained plenty involved in the passing game (15 targets over his past three games), but there is no denying that his biggest growth from last season to this one is in his ability to find paydirt with eight more rushing scores this year on 100 fewer carries than 2023.
The spiking touchdown rate has fueled a 23.8% increase in PPR points per touch for Cook, and while Ray Davis has looked the part when given the opportunity, it’s clear that Buffalo is comfortable with a bell-cow situation.
The 49ers own a top-10 run defense in nearly every metric you should be interested in, and while that hurts the upside case for Cook this week, his volume and versatility keep him ranked as a must-start in all formats without much question.
Are you looking for start/sit advice for other players in your lineup? Read our Week 13 Fantasy Start-Sit Advice Cheat Sheet for every fantasy-relevant player in every game.
James Cook’s Fantasy Points Projection in Week 13
As of 8 AM ET on Sunday morning, Cook is projected to score 14.8 fantasy points in PPR formats. This includes 15.7 rushing attempts for 81.8 yards and 0.2 touchdowns. It also includes 1.3 receptions for 29 yards and 0.2 touchdowns.
Check out the free PFN Fantasy Start-Sit Optimizer for the latest projections and advice for your lineups this week.
James Cook’s Fantasy Ranking
Our Weekly Consensus PPR Rankings are below — both positional and overall. They were last updated at 3:45 AM ET on Wednesday, December 25. If you're in a Superflex league, make sure you check out our Weekly Consensus Superflex Rankings.
Week 17 RB PPR Rankings
1) Saquon Barkley | PHI (vs. DAL)
2) Jahmyr Gibbs | DET (at SF)
3) Derrick Henry | BAL (at HOU)
4) Bijan Robinson | ATL (at WAS)
5) Josh Jacobs | GB (at MIN)
6) De'Von Achane | MIA (at CLE)
7) Jonathan Taylor | IND (at NYG)
8) Chase Brown | CIN (vs. DEN)
9) Kyren Williams | LAR (vs. ARI)
10) James Conner | ARI (at LAR)
11) Bucky Irving | TB (vs. CAR)
12) Chuba Hubbard | CAR (at TB)
13) James Cook | BUF (vs. NYJ)
14) Breece Hall | NYJ (at BUF)
15) Joe Mixon | HOU (vs. BAL)
16) Aaron Jones | MIN (vs. GB)
17) Jerome Ford | CLE (vs. MIA)
18) Tony Pollard | TEN (at JAX)
19) Brian Robinson Jr. | WAS (vs. ATL)
20) D'Andre Swift | CHI (vs. SEA)
21) Rico Dowdle | DAL (at PHI)
22) Isaac Guerendo | SF (vs. DET)
23) Rhamondre Stevenson | NE (vs. LAC)
24) Rachaad White | TB (vs. CAR)
25) Tyrone Tracy Jr. | NYG (vs. IND)
26) Zach Charbonnet | SEA (at CHI)
27) Alexander Mattison | LV (at NO)
28) Isiah Pacheco | KC (at PIT)
29) Tyjae Spears | TEN (at JAX)
30) Kendre Miller | NO (vs. LV)
31) Travis Etienne Jr. | JAX (vs. TEN)
32) Jaylen Warren | PIT (vs. KC)
33) Javonte Williams | DEN (at CIN)
34) Justice Hill | BAL (at HOU)
35) Najee Harris | PIT (vs. KC)
36) Gus Edwards | LAC (at NE)
37) Tank Bigsby | JAX (vs. TEN)
38) Ameer Abdullah | LV (at NO)
39) Kareem Hunt | KC (at PIT)
40) Devin Singletary | NYG (vs. IND)
41) Tyler Allgeier | ATL (at WAS)
42) Kimani Vidal | LAC (at NE)
43) Audric Estimé | DEN (at CIN)
44) Raheem Mostert | MIA (at CLE)
45) Ray Davis | BUF (vs. NYJ)
46) Antonio Gibson | NE (vs. LAC)
47) Kenneth Gainwell | PHI (vs. DAL)
48) Craig Reynolds | DET (at SF)
49) Cam Akers | MIN (vs. GB)
50) Ty Johnson | BUF (vs. NYJ)
51) Blake Corum | LAR (vs. ARI)
52) Patrick Taylor Jr. | SF (vs. DET)
53) Roschon Johnson | CHI (vs. SEA)
54) Braelon Allen | NYJ (at BUF)
55) Jeremy McNichols | WAS (vs. ATL)
56) Jaleel McLaughlin | DEN (at CIN)
57) Isaiah Davis | NYJ (at BUF)
58) D'Onta Foreman | CLE (vs. MIA)
59) Cordarrelle Patterson | PIT (vs. KC)
60) Jamaal Williams | NO (vs. LV)
61) Emanuel Wilson | GB (at MIN)
62) DeeJay Dallas | ARI (at LAR)
63) Keaton Mitchell | BAL (at HOU)
64) Chris Brooks | GB (at MIN)
65) Pierre Strong Jr. | CLE (vs. MIA)
66) Ke'Shawn Vaughn | SF (vs. DET)
67) Trey Benson | ARI (at LAR)
68) Kenneth Walker III | SEA (at CHI)
69) Michael Carter | ARI (at LAR)
70) Sean Tucker | TB (vs. CAR)
71) Samaje Perine | KC (at PIT)
72) Israel Abanikanda | SF (vs. DET)
73) Ezekiel Elliott | DAL (at PHI)
74) Khalil Herbert | CIN (vs. DEN)
75) Dare Ogunbowale | HOU (vs. BAL)
76) Jaylen Wright | MIA (at CLE)
77) Kyle Juszczyk | SF (vs. DET)
78) Trey Sermon | IND (at NYG)
79) Mike Boone | CAR (at TB)
80) Chris Rodriguez Jr. | WAS (vs. ATL)
81) Dameon Pierce | HOU (vs. BAL)
82) Sione Vaki | DET (at SF)
83) Hunter Luepke | DAL (at PHI)
84) Alec Ingold | MIA (at CLE)
85) Tyler Goodson | IND (at NYG)