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    Seahawks vs. 49ers Prediction, Picks, Odds Today: Brock Purdy, Christian McCaffrey Look To Take Down Seattle

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    Can Seattle keep it close in this Seahawks vs. 49ers matchup if QB Geno Smith can't play? We'll break down the odds and offer a best bet prediction.

    The matchup between the Seattle Seahawks and San Francisco 49ers features the biggest spread of the week. But will this game really be the blowout fans are expecting? Let’s take a look at this contest and see if it does, in fact, deserve a double-digit spread.

    Seahawks vs. 49ers Betting Lines, Start Time, and More

    All odds from DraftKings Sportsbook.

    • Spread: 49ers -13.5
    • Moneyline: Seahawks (+650), 49ers (-1000)
    • Over/Under: 46
    • Game time: 4:05 p.m. ET
    • Location: Levi’s Stadium
    • Channel: FOX

    Seahawks vs. 49ers Prediction

    If you’re the Seahawks, the last thing you want heading on the road to face the hottest team in the league is injury concerns. But that’s where we are with the Seahawks, as the status of quarterback Geno Smith and running backs Kenneth Walker III and Zach Charbonnet are uncertain (more on that below).

    For now, the focus should be on just how dominating the 49ers have been of late. Since coming off their Week 9 bye, the 49ers are 4-0 and have won those games by margins of 31, 13, 18, and 23 points. That’s an average margin of 21.3 points per game.

    They have allowed four offensive touchdowns combined and 12.3 ppg over those four games. Opponents are averaging only 265 yards per game in those games, with San Francisco coming up with eight takeaways (while only committing one turnover on offense).

    It’s hard to imagine what the Seahawks can do to combat this domination. Just two games ago, Seattle found itself down 24-3 at the half and never got within one score.

    49ers QB Brock Purdy is enjoying an impressive run during this four-game win streak. Since returning from the bye, Purdy has completed 74% of his passes for 288 passing yards per game, with 11 TD passes, one interception, and an eye-opening passer rating of 138.3.

    In his brief career, Purdy has faced the Seahawks three times — including the playoffs — and the 49ers are 3-0, with Purdy throwing six touchdowns to only one interception.

    MORE: NFL Team Over/Under Standings

    The Seahawks could head into this contest without their starting quarterback and one of their top two running backs, if not both. QB Geno Smith (groin) is listed as questionable, but the fact that Seattle signed veteran Sean Mannion to the practice squad this week must raise some questions as to exactly how available Smith will be Sunday.

    Running backs Kenneth Walker III (oblique) and Zach Charbonnet (knee) are both listed as questionable, but indications are that both should be available by game time.

    For the 49ers, their biggest injury issues is probably defensive tackle Arik Armstead, who will miss Sunday’s game with foot and knee issues.

    Baring something unforeseen, this will be the fourth time this season the 49ers have been favored by 10 or more points. They have covered two of those three games, with the only non-cover coming by a half-point.

    MORE: PFN’s FREE NFL Playoff Predictor

    Seattle is 6-3 against the spread vs. teams from the NFC, and it is 4-2 ATS on the road.

    San Francisco hasn’t just been beating teams of late, it has been dominating them. Should we expect anything less from a team that handily beat this same opponent back on Thanksgiving?

    For me, at some point, the 49ers have come back to reality with the rest of us, right? While I think they will win, I’m fine taking a two-touchdown spread.

    Now, if Geno Smith is unavailable, that is a much different story. But for now, assuming everyone questionable can play, I think the Seahawks keep it a little closer than most think.

    Best Bet: Seahawks +13.5 (-108 at DraftKings Sportsbook)

    Our Betting Lines page has the freshest lines and promos to get BANG for your buck. PFN’s FREE Parlay Calculator and Betting Odds Calculator are also available for your betting process! New to sports betting? Check out our guide on How to Bet on the NFL. Visit our Sports Betting Legal Tracker on how to bet legally in the U.S. 

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